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Domain join or not to Domain join?

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Hi,

We're going through a major growth spurt and will be deploying 50 laptops to a group of home health nurses.  These nurses will live primarily on the road, maybe stopping in to the building once a week or so.  They will be using a mobile version of the main business app they use, which will require them to connect in using VPN to sync their data and get updates about twice a day.

I'm planning on managing my Windows 10 desktops and laptops using Intune (which I'm trying to learn) and my question is, should I domain join this laptops or not and why or why not?

We are also migrating to Office 365 and are planning on having these users use the web-based versions and store their files in OneDrive.

Recommendations, comments and opinions are welcome.  How would you approach this?

Thanks in advance!


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